The antimutagenic effect of monoterpenes against UV-irradiation-, 4NQO- and t-BOOH-induced mutagenesis in coli | Zendy

Biljaikolić | Zendy; Dragana Mitić-Ćulafić | Zendy; Branka VukovićGačić | Zendy; Jelena KneževićVukčević | Zendy

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The antimutagenic effect of monoterpenes against UV-irradiation-, 4NQO- and t-BOOH-induced mutagenesis in coli

Author(s) -

Biljaikolić,

Dragana Mitić-Ćulafić,

Branka VukovićGačić,

Jelena KneževićVukčević

Publication year - 2011

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1101117n

Subject(s) - reversion , mutagenesis , escherichia coli , chemistry , linalool , camphor , strain (injury) , dna , mutation , myrcene , mutagen , eucalyptol , biochemistry , biology , food science , essential oil , organic chemistry , gene , limonene , phenotype , anatomy

The aim of this work was to investigate the antimutagenic potential of monoterpenes from sage and basil in Escherichia coli. The mutagenic potential of monoterpenes was pre-screened with Salmonella/microsome reversion assay in strain TA100 and no mutagenic effect was detected. The antimutagenic potential against UV- 4NQO- and t-BOOH induced mutagenesis was evaluated in E. coli K12 and E. coli WP2 by reversion assays. The obtained results indicate that camphor and thujone reduce UV- and 4NQO-induced mutations; myrcene reduces t-BOOH-induced mutations, while eucalyptol and linalool reduce mutagenicity by all tested mutagens. Considering evolutionary conservation of DNA repair and antioxidative protection, the obtained results indicate that further antigenotoxicity studies should be undertaken in eukaryotes

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