Effects of bacterial lipopolysaccharide exposure on immune responsiveness in a rodent model of Parkinson’s disease | Zendy

Lucian Hrițcu | Zendy; Marius Ștefan | Zendy; Costica Misaila | Zendy; Alin Ciobîcă | Zendy; Gabriela Dumitru | Zendy

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Effects of bacterial lipopolysaccharide exposure on immune responsiveness in a rodent model of Parkinson’s disease

Author(s) -

Lucian Hrițcu,

Marius Ștefan,

Costica Misaila,

Alin Ciobîcă,

Gabriela Dumitru

Publication year - 2011

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1101099h

Subject(s) - lipopolysaccharide , immune system , substantia nigra , parkinson's disease , phagocytosis , immunology , hemoglobin , disease , biology , endocrinology , medicine , chemistry

The effects of lipopolysaccharide (LPS) on immune modulation in rats subjected to a right-unilateral lesion of the substantia nigra neurons by means of 6-hydroxydopamine (6-OHDA), were investigated. LPS administration (250 μg) significantly decreases the total number of leukocytes and erythrocytes, as well as the hemoglobin level in the 6-OHDAlesioned rats. In addition, LPS administration was also associated with an increase, relative to control, in the erythrocyte indexes and the phagocytosis by neutrophils, and in blastic transformation of T lymphocytes. The obtained data indicated that LPS exposure might represent a risk factor for the development of the immunological changes associated with Parkinson’s disease

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