Case-control study of apoE gene polymorphism in young CHD patients and controls in the Serbian population | Zendy

I. Djan | Zendy; Edita Stokić | Zendy; Dejan Sakač | Zendy; Mihajla Djan | Zendy; Dragana Obreht | Zendy; Marko Erak | Zendy; Nataša Jovanović | Zendy

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Case-control study of apoE gene polymorphism in young CHD patients and controls in the Serbian population

Author(s) -

I. Djan,

Edita Stokić,

Dejan Sakač,

Mihajla Djan,

Dragana Obreht,

Marko Erak,

Nataša Jovanović

Publication year - 2011

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1101089d

Subject(s) - waist , genotype , medicine , allele , polymorphism (computer science) , apolipoprotein e , anthropometry , apolipoprotein b , allele frequency , gene polymorphism , blood pressure , endocrinology , body mass index , biology , genetics , gene , cholesterol , disease

Apolipoprotein E displays polymorphism with three common alleles, e2, e3, and e4. The aim of this research was to determine apoE gene polymorphism in a group of healthy patients and a group of patients with CHD, and to reveal the relation between anthropometric and biochemical parameters and the apoE genotype. In CHD group significantly higher values of blood pressure, waist circumference, BMI and fat %, triglycerides, insulin (HOMA IR) and CRP were found. A statistically significant higher presence of the e3e4 genotype and e4 allele was detected in the CHD group. Statistically significant differences between waist circumference, BMI, insulin and HOMA IR were found between subjects with e3e3 and e3e4 genotypes

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