Glutathione status in the blood of rats after reticulocytosis induced by phenylhydrazine and bleeding | Zendy

Snežana Marković | Zendy; Ana Obradović | Zendy; Jovana Žižić | Zendy; Branka I. Ognjanović | Zendy; Andraš Š. Štajn | Zendy; Zorica S. Saičić | Zendy; Mihajlo Spasić | Zendy

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Glutathione status in the blood of rats after reticulocytosis induced by phenylhydrazine and bleeding

Author(s) -

Snežana Marković,

Ana Obradović,

Jovana Žižić,

Branka I. Ognjanović,

Andraš Š. Štajn,

Zorica S. Saičić,

Mihajlo Spasić

Publication year - 2010

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1003589m

Subject(s) - reticulocytosis , glutathione , phenylhydrazine , chemistry , oxidative stress , lipid peroxidation , reactive oxygen species , medicine , endocrinology , in vivo , blood plasma , biochemistry , pharmacology , biology , anemia , enzyme , microbiology and biotechnology , medicinal chemistry

In this experiment, we compared the in vivo effects of phenylhydrazine (PHZ) and bleeding treatment on the redox status and glutathione antioxidative mechanism parameters in the plasma and red blood cells (RBC) of rats. Results showed a lower level of reactive oxygen species (ROS), a higher level of lipid peroxidation and the effective antioxidative role of the glutathione system in the blood of bleeding rats. PHZ-treatment induced higher concentrations of ROS and an accumulation of oxidized glutathione in the plasma, while the glutathione system showed a satisfactory antioxidative capacity in the RBC of rats. When comparing the two anemic groups, the PHZ-treated rats showed marked oxidative stress in the plasma.

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