Pro12Ala gene polymorphism in the peroxisome proliferator-activated receptor gamma as a risk factor for the onset of type 2 diabetes mellitus in the Serbian population | Zendy

Sanja Šoškić | Zendy; Aleksandra Stanković | Zendy; Tamara Djurić | Zendy; Maja Živković | Zendy; Petar Ristić | Zendy; Zoran Andjelković | Zendy; Mirjana Šumarac-Dumanović | Zendy; Dragan Alavantić | Zendy

Open Access

Pro12Ala gene polymorphism in the peroxisome proliferator-activated receptor gamma as a risk factor for the onset of type 2 diabetes mellitus in the Serbian population

Author(s) -

Sanja Šoškić,

Aleksandra Stanković,

Tamara Djurić,

Maja Živković,

Petar Ristić,

Zoran Andjelković,

Mirjana Šumarac-Dumanović,

Dragan Alavantić

Publication year - 2010

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1002263s

Subject(s) - type 2 diabetes mellitus , peroxisome proliferator activated receptor , medicine , allele , endocrinology , serbian , population , allele frequency , polymorphism (computer science) , gene polymorphism , risk factor , genetics , diabetes mellitus , gene , receptor , biology , environmental health , linguistics , philosophy

The peroxisome proliferator-activated receptor gamma (PPARγ) is a gene candidate for the onset of type 2 diabetes mellitus (T2DM). We investigated the association of the PPARγ Pro12Ala gene with the onset of T2DM for the first time in the Serbian population. The study population consisted of 197 controls and 163 T2DM patients. The 12Ala allele tended to be more frequent in the group of T2DM patients (0.11) compared to the control subjects (0.09). The results from this study indicate that the PPARγ2 12Ala allele presents a non-significant risk factor for T2DM development in the Serbian population

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