Effects of cisplatin on lipid peroxidation and the glutathione redox status in the liver of male rats: The protective role of selenium | Zendy

Ivana Trbojević | Zendy; Branka I. Ognjanović | Zendy; Natasa Djordjevic | Zendy; Snežana Marković | Zendy; Andraš Š. Štajn | Zendy; Jelena P. Gavrić | Zendy; Zorica S. Saičić | Zendy

Open Access

Effects of cisplatin on lipid peroxidation and the glutathione redox status in the liver of male rats: The protective role of selenium

Author(s) -

Ivana Trbojević,

Branka I. Ognjanović,

Natasa Djordjevic,

Snežana Marković,

Andraš Š. Štajn,

Jelena P. Gavrić,

Zorica S. Saičić

Publication year - 2010

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1001075t

Subject(s) - glutathione , lipid peroxidation , selenium , chemistry , oxidative stress , antioxidant , toxicity , pharmacology , gpx4 , biochemistry , cisplatin , endocrinology , medicine , glutathione peroxidase , biology , enzyme , chemotherapy , organic chemistry

The role of oxidative stress in cisplatin (CP) toxicity and its prevention by pretreatment with selenium (Se) was investigated. Male Wistar albino rats were injected with a single dose of cisplatin (7.5 mg CP/kg b.m., i.p.) and selenium (6 mg Se/kg b.m, as Na2SeO3, i.p.) alone or in combination. The results suggest that CP intoxication induces oxidative stress and alters the glutathione redox status: reduced glutathione (GSH), oxidized glutathione (GSSG) and the GSH/GSSG ratio (GSH RI), resulting in increased lipid peroxidation (LPO) in rat liver. The pretreatment with selenium prior to CP treatment showed a protective effect against the toxic influence of CP on peroxidation of the membrane lipids and an altering of the glutathione redox status in the liver of rats. From our results we conclude that selenium functions as a potent antioxidant and suggest that it can control CP-induced hepatotoxicity in rats

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