The effect of paclitaxel alone and in combination with cycloheximide on the frequency of premature centromere division in vitro | Zendy

Vladan Bajić | Zendy; Zoran Stanimirović | Zendy; Jevrosima Stevanović | Zendy; Z Milićević | Zendy; Lada Živković | Zendy; Biljana SpremoPotparević | Zendy

Open Access

The effect of paclitaxel alone and in combination with cycloheximide on the frequency of premature centromere division in vitro

Author(s) -

Vladan Bajić,

Zoran Stanimirović,

Jevrosima Stevanović,

Z Milićević,

Lada Živković,

Biljana SpremoPotparević

Publication year - 2010

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1001063b

Subject(s) - centromere , paclitaxel , cycloheximide , micronucleus test , chromosome instability , biology , fluorescence in situ hybridization , micronucleus , chromosome aberration , chromosome , cancer research , genotoxicity , microbiology and biotechnology , cancer , genetics , medicine , cell culture , toxicity , gene

Premature centromere division (PCD) can be viewed as a manifestation of chromosome instability. In order to evaluate the ability of Paclitaxel (Ptx) and Cycloheximide (Cy) to induce PCD we used a cytokinesis block micronucleus assay (CBMN), fluorescent in situ hybridization (FISH), and the chromosome aberration (CA) assay in human peripheral blood lymphocytes. Results showed that Ptx can induce PCD alone or in combination with Cy. These findings call us to pay more attention to PCD as a parameter of genotoxicity in the pre-clinical research of mono and/or combinational therapies for cancer treatment

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