Fumagillin-induced chromosome aberrations in mouse bone-marrow cells | Zendy

Zoran Stanimirović | Zendy; Nevenka Aleksić | Zendy; Milan Kulić | Zendy; Milan Maletic | Zendy

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Fumagillin-induced chromosome aberrations in mouse bone-marrow cells

Author(s) -

Zoran Stanimirović,

Nevenka Aleksić,

Milan Kulić,

Milan Maletic

Publication year - 2010

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1001047s

Subject(s) - fumagillin , genotoxicity , mitotic index , bone marrow , microbiology and biotechnology , biology , autosome , metaphase , chromosome , chemistry , mitosis , andrology , immunology , genetics , medicine , toxicity , gene , angiogenesis , organic chemistry

The genotoxicity of fumagillin was evaluated assessing the mitotic index and chromosome aberrations in mouse bone-marrow cells. Mice were given fumagillin orally in doses 5, 10 and 20 mg/kg bw. All doses significantly (p<0.001) reduced the mitotic index. The medium and maximum doses led to significant (p<0.01 and p<0.001, respectively) increases in numeric aberrations. The highest dose induced both structural and numeric aberrations (p<0.001), and insertions on the first pair of autosomes that were amplified in the 1C and 1E regions. These results pointed to the genotoxic potential of fumagillin in the range of medium and maximum doses applied

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