Mitotic activity of smooth muscle cells of the myoma: Does hormonal stimulation have an effect on the number of mitoses? | Zendy

Tatjana Kastratović | Zendy; Irena Tanasković | Zendy; Vesna Lačković | Zendy; Marija Šorak | Zendy; Vesna Stanković | Zendy; Biljana Ljujić | Zendy; Srdjan Sedlar | Zendy; Aleksandar Živanović | Zendy

Open Access

Mitotic activity of smooth muscle cells of the myoma: Does hormonal stimulation have an effect on the number of mitoses?

Author(s) -

Tatjana Kastratović,

Irena Tanasković,

Vesna Lačković,

Marija Šorak,

Vesna Stanković,

Biljana Ljujić,

Srdjan Sedlar,

Aleksandar Živanović

Publication year - 2010

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs1001039k

Subject(s) - mitosis , follicular phase , myoma , menstrual cycle , endometrium , luteal phase , biology , uterus , medicine , hormone , mitotic index , endocrinology , stimulation , andrology , microbiology and biotechnology

Myomas develop as a result of increased mitotic (proliferating) activity of smooth muscle cells. In this study we examined the pathohistological samples of 176 myomas and their endometria that were obtained after hysterectomy from patients in the proliferative (follicular) and secretory (luteal) phase of the menstrual cycle. We examined the mitotic activity of the myoma cells in both phases and established that the average number of mitoses in the proliferative phase was significantly larger compared to the secretory phase, and that in the proliferative phase of the cycle there exists a statistically significant convergent association of the number of mitoses in the endometrium and in myomas. The number of endometrial mitoses is significantly larger than in myomas in both phases of the cycle

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