Correlation between steroid receptors, angiogenic factors, and classical prognostic parameters in node-negative breast cancer patients | Zendy

Tijana Vujasinović | Zendy; Milan Markićević | Zendy; Abu Rabi | Zendy; Dragica NikolićVukosavljević | Zendy

Open Access

Correlation between steroid receptors, angiogenic factors, and classical prognostic parameters in node-negative breast cancer patients

Author(s) -

Tijana Vujasinović,

Milan Markićević,

Abu Rabi,

Dragica NikolićVukosavljević

Publication year - 2009

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs0904599v

Subject(s) - breast cancer , estrogen receptor , medicine , angiogenesis , correlation , oncology , receptor , positive correlation , biomarker , endocrinology , estrogen , cancer , cancer research , biology , biochemistry , geometry , mathematics

Breast cancer (BC) progression is an estrogen receptor (ER) signaling- and angiogenesis-dependent process. This study investigated relationships between classical prognostic factors and biomarkers ER, PR, VEGF, and bFGF in node-negative BC patients. Positive correlation between ER and both PR (p < 0.001) or FGF (p = 0.04) levels indicates ER-regulated expression of these factors and a potential synergistic effect of ER and bFGF in tumor progression. Aside from correlation of age with ER and bFGF levels (p = 0.003; p = 0.05; respectively), no correlation of biomarkers with classical prognostic parameters was found, indicating that those biomarkers could be independent prognostic factors

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