Inhibition of mitochondrial Na-dependent Ca2+ efflux from rat brain stem by 17β-estradiol | Zendy

Snježana Petrović | Zendy; Maja Milošević | Zendy; Ivana Stanojević | Zendy; Nataša Veličković | Zendy; Dunja Drakulić | Zendy; Anica Horvat | Zendy

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Inhibition of mitochondrial Na-dependent Ca2+ efflux from rat brain stem by 17β-estradiol

Author(s) -

Snježana Petrović,

Maja Milošević,

Ivana Stanojević,

Nataša Veličković,

Dunja Drakulić,

Anica Horvat

Publication year - 2009

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs0902171p

Subject(s) - efflux , calcium , mitochondrion , homeostasis , chemistry , medicine , endocrinology , flux (metallurgy) , free nerve ending , calcium metabolism , membrane potential , microbiology and biotechnology , biophysics , biology , biochemistry , organic chemistry

The role of membrane-bound estradiol in modulation of mitochondrial Ca2+ flux in nerve endings isolated from rat brain stem was examined. Physiological concentrations of 17β-estradiol bind specifically to isolated mitochondria (Bmax 33.8 ± 2.5 fmoles estradiol/mg of protein, Km 0.185 ± 0.006 nmoles/l free estradiol). At concentrations ranging from 1 x 10-10 to 2 x 10-9 moles/l, estradiol significantly (by 23-28%) decreases mitochondrial Na-dependent calcium efflux. Decreased calcium efflux was associated with increased affinity of the Na+/Ca2+ exchanger for Na+ and decreased capacity of the exchanger to extrude Ca2+. Calcium ion efflux modulation and mitochondrial ion retention may be the way that 17β-estradiol exerts its role in nerve cell homeostasis

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