Apoptosis of human fetal pancreatic islets during short-term culture | Zendy

Predrag Djordjević | Zendy; Vesna Dimitrijević-Srećković | Zendy; Vesna Bumbaširević | Zendy; Radoje Čólović | Zendy; Dragan Nikolić | Zendy; N. Raketić | Zendy; F. Canović | Zendy

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Apoptosis of human fetal pancreatic islets during short-term culture

Author(s) -

Predrag Djordjević,

Vesna Dimitrijević-Srećković,

Vesna Bumbaširević,

Radoje Čólović,

Dragan Nikolić,

N. Raketić,

F. Canović

Publication year - 2009

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs0901009d

Subject(s) - apoptosis , islet , in vitro , pancreatic islets , fetus , endocrinology , function (biology) , transplantation , medicine , cell culture , insulin , organ culture , andrology , microbiology and biotechnology , biology , cancer research , pregnancy , biochemistry , genetics

We investigated the influence of short-term culture in vitro on the appearance of apoptosis of human fetal pancreatic islets (HFIs) and its effect on the mass and insulin-secretory capacity (ISC) of β-cells. It was found that apoptosis was present from the end of the culture period, increasing as a function of time and leading to decrease of β-cell mass. At the same time, ISC decreased. The decrease of β-cell mass and ISC may influence significantly the clinical outcome of HFIs transplantation in type 1 diabetic patients

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