Cytotoxic, antioxidant, and antimicrobial activities of Ampelopsis brevipedunculata and Parthenocissus tricuspidata (Vitaceae) | Zendy

Tatjana Kundaković | Zendy; Tatjana Stanojković | Zendy; Marina Milenković | Zendy; Jasmina Grubin | Zendy; Zorica D. Juranić | Zendy; Branka Stevanović | Zendy; Nada Kovačević | Zendy

Open Access

Cytotoxic, antioxidant, and antimicrobial activities of Ampelopsis brevipedunculata and Parthenocissus tricuspidata (Vitaceae)

Author(s) -

Tatjana Kundaković,

Tatjana Stanojković,

Marina Milenković,

Jasmina Grubin,

Zorica D. Juranić,

Branka Stevanović,

Nada Kovačević

Publication year - 2008

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs0804641k

Subject(s) - dpph , chemistry , vitaceae , antimicrobial , cytotoxicity , traditional medicine , antioxidant , ic50 , biochemistry , botany , biology , in vitro , medicine , organic chemistry , vitis vinifera

Cyclohexane and methanol extracts of leaves and inflorescences of Ampelopsis brevipedunculata and Parthenocissus tricuspidata are shown to exert significant cytotoxic action on both estrogen-dependent (MDA-MB-361) and estrogen-nondependent (MDA-MB-453) breast cancer cell lines. Methanol extracts of P. tricuspidata exhibited higher cytotoxicity for the MDA-MB-453 cell line (inflorescence: IC50 =111.45 ± 2.56 μg/ml; leaves: IC50= 56.76 ± 7.11 μg/ml) than for MDA-MB-361. Cyclohexane extracts of A. brevipedunculata leaves exhibited high cytotoxicity against MDA-MB-453 (IC50 =78.32 ± 0.1 μg/ml) and the estrogen-dependent MDA-MB-361 cell line (IC50 =97.40 ± 2.61 μg/ml). The highest DPPH-scavenging ability was exhibited by methanol extracts of P. tricuspidata inflorescences, with IC50=7.55±0.07 μg/ml. The tested extracts possessed weak antimicrobial activity

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