Influence of vitamin C supplementation on the oxidative status of rat liver | Zendy

Siniša Djurašević | Zendy; Jelena Djordjević | Zendy; Tamara Drenca | Zendy; Nebojša Jasnić | Zendy; Gordana Cvijić | Zendy

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Influence of vitamin C supplementation on the oxidative status of rat liver

Author(s) -

Siniša Djurašević,

Jelena Djordjević,

Tamara Drenca,

Nebojša Jasnić,

Gordana Cvijić

Publication year - 2008

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs0802169d

Subject(s) - ascorbic acid , vitamin c , oxidative phosphorylation , vitamin , endogeny , medicine , endocrinology , liver tissue , vitamin e , antioxidant , chemistry , biology , biochemistry , food science

Rats have the ability to synthesize vitamin C in the liver. In the present work, we tested whether its additional intake improves antioxidative protection of the tissue. Thus, we studied the liver’s oxidative status in rats given two supplements of ascorbic acid over a four-week period of time. Our results confirmed that the additional intake of ascorbate improves the liver’s antioxidative defense in a dose-dependent manner. The explanation for the disproportion between the ratio of employed doses of vitamin C and their effects on the studied parameters probably lies in the mechanism of tissue accumulation of ascorbate and balance of its alimentary and endogenous availability

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