Effect of protamine sulfate on the isolated mesenteric arteries of normotensive and spontaneously hypertensive rats | Zendy

Zorana Oreščanin-Dušić | Zendy; Srđan Milovanović | Zendy; Mihajlo Spasić | Zendy; Ratko Radojičić | Zendy; Duško Blagojević | Zendy

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Effect of protamine sulfate on the isolated mesenteric arteries of normotensive and spontaneously hypertensive rats

Author(s) -

Zorana Oreščanin-Dušić,

Srđan Milovanović,

Mihajlo Spasić,

Ratko Radojičić,

Duško Blagojević

Publication year - 2008

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs0802163o

Subject(s) - protamine sulfate , mesenteric arteries , medicine , endocrinology , protamine , chemistry , relaxation (psychology) , endothelium , artery , heparin

We tested the relaxant effect of increased protamine sulfate (PS) amounts (10, 20, 50, 100 and 150 μg/ml) on the isolated mesenteric arteries of normotensive and spontaneously hypertensive (SH) rats, with or without endothelium. PS caused concentration-dependent relaxation of isolated mesenteric arteries in both types of rats. The relaxation effect of PS was lower in SH rats than in normotensive ones. Our results indicate that the vascular smooth muscles play a significant role in PS-mediated relaxation

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