Adrenal cortex in peripubertal and adult female rats after neonatal treatment with SRIH-14 | Zendy

Verica Milošević | Zendy; Milica Terzić | Zendy; Branko Filipović | Zendy; Milica ManojlovićStojanoski | Zendy; Branka ŠošićJurjević | Zendy; Milka Sekulić | Zendy; Vesna Starčević | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Adrenal cortex in peripubertal and adult female rats after neonatal treatment with SRIH-14

Author(s) -

Verica Milošević,

Milica Terzić,

Branko Filipović,

Milica ManojlovićStojanoski,

Branka ŠošićJurjević,

Milka Sekulić,

Vesna Starčević

Publication year - 2008

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs0801041m

Subject(s) - medicine , endocrinology , adrenal cortex , cortex (anatomy) , biology , saline , adrenal gland , neuroscience

Neonatal female rats (3-7 days old) were injected subcutaneously twice daily with 20 μg of SRIH-14/100g b.w. for five consecutive days. The animals were sacrificed in the peripubertal (38 days old) or adult (80 days old) periods of life. Control rats were treated in the same way with identical volumes of saline. SRIH-14 led to significant reduction (p<0.05) of the absolute and relative volumes of the ZG in peripubertal animals, by 11 and 22%, respectively in comparison with the controls. The total number and volume of ZG cells and their nuclei were also significantly decreased (p<0.05) in peripubertal SRIH-14-treated rats as compared to the controls. There were no significant (p>0.05) changes in the morphometric parameters of adult adrenal cortex after SRIH-14 treatment compared with control females. It can be concluded that subcutaneously applied SRIH-14 in the neonatal period inhibits growth of adrenal ZG cells in female rats only up to the peripubertal stage, while the adrenal gland cortex recovers before mature adulthood is reached

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research