Steroid hormones modulate galectin-1 in the trophoblast HTR-8/SVneocell line | Zendy

Žanka BojićTrbojević | Zendy; Milica Božić | Zendy; Ljiljana Vićovac | Zendy

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Steroid hormones modulate galectin-1 in the trophoblast HTR-8/SVneocell line

Author(s) -

Žanka BojićTrbojević,

Milica Božić,

Ljiljana Vićovac

Publication year - 2008

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs0801011b

Subject(s) - mifepristone , matrigel , dexamethasone , trophoblast , steroid , hormone , chemistry , medicine , cell culture , endocrinology , biology , andrology , cell , biochemistry , placenta , pregnancy , fetus , genetics

The effects of steroids on galectin-1 (gal-1) were studied in HTR-8/SVneo cells by immunocytochemistry, cell-based ELISA, the MTT proliferation test and the Matrigel TM invasion test. Dexamethasone (DEX), progesterone (PRG), and mifepristone (RU486) were used. Gal-1 was modulated in a steroid- and dose-dependent manner by DEX, which mildly but significantly stimulated production at low concentrations (0.1-10 nM), and inhibited it at 100 nM, while the effects of PRG and RU486 were opposite. HTR-8/SVneo cell invasion of Matrigel was significantly decreased in the presence of DEX and lactose. The obtained data support the proposed regulatory role of steroids in trophoblast gal-1 production

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