Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease | Zendy

Aleksandra Stanković | Zendy; Sanja Stanković | Zendy; Zagorka Jovanovic-Markovic | Zendy; Maja Živković | Zendy; Tamara Djurić | Zendy; Sanja Glisic-Milosavljevic | Zendy; Dragan Alavantić | Zendy

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Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease

Author(s) -

Aleksandra Stanković,

Sanja Stanković,

Zagorka Jovanovic-Markovic,

Maja Živković,

Tamara Djurić,

Sanja Glisic-Milosavljevic,

Dragan Alavantić

Publication year - 2007

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs0704303s

Subject(s) - apolipoprotein b , genotype , odds ratio , medicine , allele , disease , polymorphism (computer science) , gastroenterology , biology , gene , genetics , endocrinology , cholesterol

The plasma concentration of apoB has recently been reported to be the best lipid predictor of coronary heart disease. The possible associations of genetic markers in the apolipoprotein B gene (XbaI, EcoRI, MspI, Ins/Del, and 4311 A/G polymorphisms) were evaluated in patients with ischemic cerebrovascular disease (ICVD) and controls of equivalent BMI. The odds ratio for ICVD in the X+X+ genotype was 2.22, 95% CI 1.24-3.96 (P<0.05), while that for ICVD in the Ins/Ins genotype was 2.82, 95% CI 1.57-5.06 (P<0.05). The patients had significantly higher frequency of the 4311A allele compared to the controls (P<0.01). Our results support the assumption that apoB gene polymorphisms may contribute to the extent of cerebrovascular disease risk

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