Cytogenetic diepoxybutane sensitivity in Serbian children with Fanconi anemia | Zendy

Sanja Cirkovic | Zendy; Marija GućŠćekić | Zendy; Dragana Vujić | Zendy; Dušan Micić | Zendy

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Cytogenetic diepoxybutane sensitivity in Serbian children with Fanconi anemia

Author(s) -

Sanja Cirkovic,

Marija GućŠćekić,

Dragana Vujić,

Dušan Micić

Publication year - 2006

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs0604215c

Subject(s) - fanconi anemia , bone marrow failure , aplastic anemia , medicine , cancer , chromosome instability , pediatrics , bone marrow , genetics , immunology , chromosome , biology , haematopoiesis , dna repair , stem cell , gene

Fanconi anemia (FA) is an inherited disorder with aplastic anemia, cancer susceptibility, and hypersensitivity to alkylating agents such as diepoxybutane (DEB). The DEB test is used to screen for FA among patients with bone marrow failure syndromes (BMFS). From February of 2004 to May of 2006, 29 children with BMFS were diagnosed and treated at the Mother and Child Health Care Institute of Serbia (MCHIS). In the examined group, five out of 29 patients (17.2%) were found to have increased DEB-induced chromosome breakage (0.58-2.15 vs. 0.00-0.20 breaks/cell; p<0.001) with no overlap. Our results suggest the importance of this analysis for differential diagnosis and adequate therapy of FA among patients with BMFS

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