Kainate-induced oxidative stress and neurotoxicity in the rat brain | Zendy

Lidija Radenović | Zendy; Vesna Selaković | Zendy

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Kainate-induced oxidative stress and neurotoxicity in the rat brain

Author(s) -

Lidija Radenović,

Vesna Selaković

Publication year - 2005

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs0504259r

Subject(s) - neurotoxicity , kainate receptor , superoxide , forebrain , oxidative stress , hippocampus , chemistry , neuroscience , kainic acid , biology , central nervous system , glutamate receptor , biochemistry , toxicity , receptor , organic chemistry , ampa receptor , enzyme

We investigated superoxide production and MnSOD activity after kainate injection into the CA3 region of the rat hippocampus. The measurements took place at different times in hippocampus, forebrain cortex, striatum, and cerebellum homogenates. Free radicals including superoxide are responsible for post-lesional cytotoxicity. Neuronal cells responded to oxidative stress in kainate-induced neurotoxicity and caused the protective mechanism to increase MnSOD levels. The increase of MnSOD in distinct brain regions functionally connected via afferents and efferent suggests that these regions are affected by the injury. It implies that MnSOD protects the cells in these regions from superoxide-induced damage and therefore may limit the retrograde and anterograde spread of neurotoxicity

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