Antimutagenic effect of essential oil of sage (Salvia officinalis L.) and its fractions against UV-induced mutations in bacterial and yeast cells | Zendy

Jelena KneževićVukčević | Zendy; Branka VukovićGačić | Zendy; Tatjana Stević | Zendy; Jasna Stanojević | Zendy; Biljaikolić | Zendy; Draga Simić | Zendy

Open Access

Antimutagenic effect of essential oil of sage (Salvia officinalis L.) and its fractions against UV-induced mutations in bacterial and yeast cells

Author(s) -

Jelena KneževićVukčević,

Branka VukovićGačić,

Tatjana Stević,

Jasna Stanojević,

Biljaikolić,

Draga Simić

Publication year - 2005

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs0503163k

Subject(s) - sage , salvia officinalis , reversion , terpene , yeast , essential oil , officinalis , salmonella , biology , escherichia coli , chemistry , food science , botany , biochemistry , bacteria , gene , genetics , phenotype , physics , nuclear physics

The inhibition of spontaneous and UV-induced mutations by essential oil (EO) of sage (Salvia officinalis L.) and its fractions F1-F5 containing different proportions of mono- and sesquiterpenes was studied with the Salmonella/microsome, E. coli K12, and S. cerevisiae D7 reversion assays. The EO, F1, and F2 exhibited antimutagenic potential against UV-induced mutations in all tests. Fractions F3 and F4 produced a toxic, mutagenic, or antimutagenic response, depending on the test organism used. Reduction of spontaneous and UV-induced mutations by F5 was detected only in permeable strains of E. coli. The obtained results demonstrate antimutagenic activity of volatile sage terpenes and recommend them for further antimutagenesis and anticarcinogenesis studies

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