Age dependent alterations of glucocorticoid receptors and relationship to enzyme activities in rat liver | Zendy

Mojca Vulović | Zendy; Goran Korićanac | Zendy; Esma R. Isenović | Zendy; N Ribarac-Stepić | Zendy

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Age dependent alterations of glucocorticoid receptors and relationship to enzyme activities in rat liver

Author(s) -

Mojca Vulović,

Goran Korićanac,

Esma R. Isenović,

N Ribarac-Stepić

Publication year - 2003

Publication title -

archives of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.217

H-Index - 25

eISSN - 1821-4339

pISSN - 0354-4664

DOI - 10.2298/abs0302001v

Subject(s) - glucocorticoid receptor , glucocorticoid , receptor , enzyme , göran , liver enzyme , biology , endocrinology , medicine , biochemistry , humanities , philosophy

Aging has been defined as a general decline in body function associated with an impaired ability to maintain homeostasis (K i z a k i et at. 1998). Alterations in the adaptive responses of tissues and cells to a certain hormone and other biochemical stimuli are age-related as well as the changes in the induction of some enzymes (K a lim i et al. 1983). Glucocorticoid hormones (GH) regulate development and aging and are essential for the maintenance of basal and stress-related homeostasis. The effects of glucocorticoids are exerted by intracellular glucocorticoid receptor (GR) protein, ligand dependent transcriptional factor, that binds to specific DNA sequences, glucocorticoid response elements (GRE) thereby modulating the expression of target genes in a positive or negative manner (B eat

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