Presencia de Integrones Clase 1 en Aislamientos de Staphylococcus epidermidis de las unidades de neonatología del Instituto Materno Infantil de Bogotá

Multiresistance to antimicrobial against Gram-positive bacteria, especially Staphylococcus epidermidis is a progressive problem in newborn-intensive care units. One of the recently described mechanisms of bacterial ressistance is the presence of integrons and gene cassettes. There are more than 9 types of integrons, out of which class 1 integron is the most frequently associated with strains causing hospital infections. In this study, presence of class 1 integrons in Staphylococcus epidermis was determined as coming from hemocultures and catheter points which caused nasocomial infection in newborn intensive care units of Instituto Materno Infantil in Bogota, Colombia. From the 46 studied strains, intl1 gene was detected in 21 of them (45.7%). This finding, pioneer in bacterial strains isolated in newborns, suggests the necessity to look for gene cassette which give resistance to the different anti microbial entities to define nosocomial infection treatment schemes caused by these microorganisms. This is the first time mechanism of resistance to aminoglycoside and other antimicrobials in Colombian Gram positive strains is studied. We suggest that it is important to carry out assays with gene cassette for different antibiotics of nosocomial infection to provide a better treatment selection.