A closer look at PLGA microspheres

As a microscopist, I am frequently asked to image microspheres/microparticles (and nanospheres/ particles) that are formulated from PLGA using the scanning electron Microscope (seM), for both size distribution and shape. Most researchers are concerned with obtaining a formulation that will yield a uniform particle size, which is within a desired range, and that seM images also match data from the mean particle analyser that uses light scattering techniques. In addition, sometimes it is necessary to image fractured particles to determine if they are solid or hollow. A closer look at PLGA microspheres