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The Indonesian people still empirically use medicinal plants to overcome their diseases or maintain their health. One of the medicinal plants is Cassia siamea Lamk (daun johar) used for treatment offever as well as malaria. A lot ofpeople usually use it for a long period^ of time. It is preferable for medicinal plants to have no effect rather than toxic effects. Subchronic toxicity test of the 70% ethanolic extract of the leaf of Cassia siamea Lamk have been carried out on 72 male Spraque Dawley albino rats for 3 months. The administration of the test materials were orally, every day except Sunday and there were three kinds of different dosages respectively 9,8 mg/100 g b.w.; 48 mg/100 g b.w. and 240 mg/100 g b.w. which means equivalent to lx; 5x and 25x the usual dose of man. The control group received water only. The result showed that the 70% ethanolic extract of the leaf of Cassia siamea Lamk. administered orally every day until 3 months, the dose of up to 240 mg/100 g b.w, equivalent to 25x the usual dose of man didn't show toxicological effect on the internal body organs of the test animals such as liver, lung, heart, spleen, kidney and intestine. Other parameters such as SGOT, SGPT, Hb, Ureum and Creatinin of blood serum didn't show significant differences.

TOKSISITAS SUBKRONIK EKSTRAK ETANOL DAUN JOHAR (CASSIA SIAMEA LAMK.) PADA TIKUS PUTIH