Spectrophotometric Method for Determination of Sulfamethoxazole in Pharmaceutical Preparations by Diazotization-Coupling Reaction | Zendy

Raghad Sinan | Zendy; Wasan A. Al-Uzri | Zendy

Open Access

Spectrophotometric Method for Determination of Sulfamethoxazole in Pharmaceutical Preparations by Diazotization-Coupling Reaction

Author(s) -

Raghad Sinan,

Wasan A. Al-Uzri

Publication year - 2011

Publication title -

journal of al-nahrain university-science

Language(s) - English

Resource type - Journals

eISSN - 2519-0881

pISSN - 1814-5922

DOI - 10.22401/jnus.14.3.02

Subject(s) - hydrochloric acid , chemistry , sodium nitrite , sodium hydroxide , chromatography , salt (chemistry) , sulfamethoxazole , absorption (acoustics) , nuclear chemistry , inorganic chemistry , organic chemistry , antibiotics , materials science , biochemistry , composite material

A simple, rapid and sensitive spectrophotometric method has been developed for the determination of sulfamethoxazole (SMZ) in pure form and pharmaceutical preparations. The proposed method is based on the diazotization reaction of SMZ with sodium nitrite in hydrochloric acid medium to form diazonium salt, which is coupled with 1-naphthol in sodium hydroxide medium to form azo dye, showing absorption maxima at 525 nm. Linearity was observed from 2–14 μg mL SMZ. Statistical analysis of the results and comparison with results by BrattonMarshall’s method are also reported.

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