EVALUATION OF SERUM TOTAL, LIPID AND PROTEIN ASSOCIATED SIALIC ACIDS LEVELS AS AN INFLAMMATORY MARKERS IN TYPHOID FEVER PATIENTS

Total sialic acid (TSA) and its fraction lipid and protein associated sialic acids (LASA and PASA) were measured in serum belonged to 100 patients with typhoid fever, and 50 normal subjects considered as normal healthy controls. Data analysis shows that the levels of TSA (91.58 22.15 mg/dL), LASA (28.88 7.28 mg/dL) and PASA (60.87 15.50 mg/dL) were significantly (P<0.0001) higher in serum typhoid fever patients compared with normal controls (66.0 20.0 mg/dL), (16.0 4.0 mg/dL) and (42.0 7.0 mg/dL) respectively, but there is no statistically significant differences seen between females and males patient groups in regard to TSA, LASA and PASA levels. The results showed the levels of TSA and its fraction (LASA and PASA) in typhoid fever patients are higher than normal which showed normal levels, further study is required to explore the binding of sialic acid to the specific site of proteins and lipids to consider these inflammatory markers in monitoring and progression for typhoid fever disease, and evaluating the effectiveness of various therapeutic approaches.