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The antineoplastic properties of the thiosemicarbazones ligands and their palladium(II) complexes, have become an important research subject, due to the cytotoxic activities with very promising results in the oncology field. The aim of this work was to evaluate the antiproliferative effect of the ligands derived from pyrazole-3-carbaldehyde (HL1-2), the palladium(II) bis-chelate [Pd(L)2] complexes and the [Pd(L 2 )2] complexes included witin the ß-cyclododextrin (ß-CD), against several human tumor cell lines such as HCT-15, PC-3 and HeLa, using the sulforhodamine B method. Our results showed that the inclusion of [Pd (L)2] complexes witin the β-CD caused a decrease in IC50 values against the different tumor lines tested. The ranges found of IC50 values were from 0.45 to 1.13 μM for the [Pd(MePhPzTSC)2] complex, and from 0.86 to 1.31 μM for the [Pd(Ph2PzTSC)2] complex, whereas when these palladium(II) bis-chelate complexes were included in the β-CD, an increase in antiproliferative activity (IC50 = 0.14 0.52 μ) was evidenced. These results demonstrate that when the palladium(II) complexes are alone is required 5 to 10 times less concentration than when these complexes were included in the β-CD. Also, the obtained results in this study indicate that the HeLa cell line are more sensitive to the [Pd(MePhPzTSC)2] • ß-CD compound, whereas the HCT-15 cell line was only sensitive for the [Pd(Ph2PzTSC)2] • β-CD compound. In general, this study has shown that the inclusion of palladium(II) complexes on β-CD enhances its antiproliferative activity. Recibido: 08-03-2017 Aceptado: 08-03-2018

investigación clínica

Actividad antiproliferativa in vitro, de los complejos de paladio(II) incluidos en la β-ciclodextrina, frente a varias líneas de células tumorales de humano