Production and Utilization of SPIONs for In-vitro Drug Release and X-ray Imaging | Zendy

Antony V. Samrot | Zendy; C. Saipriya | Zendy; Durga Sruthi P. | Zendy; Jenifer Selvarani A | Zendy; P. Raji | Zendy; P. Prakash | Zendy; Ponnaiah Paulraj | Zendy; R. Thirumurugan | Zendy; Sajeesh Pattammadath | Zendy; Sajna Keeyari Purayil | Zendy; P T Mohamed Javad | Zendy; P. Iyappan | Zendy

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Production and Utilization of SPIONs for In-vitro Drug Release and X-ray Imaging

Author(s) -

Antony V. Samrot,

C. Saipriya,

Durga Sruthi P.,

Jenifer Selvarani A,

P. Raji,

P. Prakash,

Ponnaiah Paulraj,

R. Thirumurugan,

Sajeesh Pattammadath,

Sajna Keeyari Purayil,

P T Mohamed Javad,

P. Iyappan

Publication year - 2020

Publication title -

journal of pure and applied microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.149

H-Index - 16

eISSN - 2581-690X

pISSN - 0973-7510

DOI - 10.22207/jpam.14.2.27

Subject(s) - drug , in vitro , chemistry , pharmacology , biology , biochemistry

In this study, SPIONs were produced in the presence of cobalt as catalyst. SPIONs formed by this chemical co-precipitation were size around 20 nm. After producing the SPIONs, it was subjected for functionalization with oleic acid and loaded with drug itraconazole (a drug possess antifungal and antibacterial activity) and encapsulated with polyhydroxybutyrate (PHB). The produced core-shell SPIONS was used for antimicrobial study against two bacteria namely Pseudomonas aeruginosa and Brevibacillus brevis and a fungi Candida albicans. It was found to be effectively releasing drug for more than 3 hours. The SPIONs alone was acting good as contrasting agent and used for enhancing

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