Taxonomic Characterization and Antagonistic Efficacy of Streptomyces cavourensis SKCMM1 Isolated from Sediment of Pichavaram Mangrove Forest | Zendy

Manikandan Madheslu | Zendy; Ashok Kumar Marimuthu | Zendy; Vaishnavi Jagannathan | Zendy; Duraimurugan Kasiviswanathan | Zendy; Baby Shakila Parimelazhagan | Zendy; Narendhran Sadasivam | Zendy

Open Access

Taxonomic Characterization and Antagonistic Efficacy of Streptomyces cavourensis SKCMM1 Isolated from Sediment of Pichavaram Mangrove Forest

Author(s) -

Manikandan Madheslu,

Ashok Kumar Marimuthu,

Vaishnavi Jagannathan,

Duraimurugan Kasiviswanathan,

Baby Shakila Parimelazhagan,

Narendhran Sadasivam

Publication year - 2018

Publication title -

journal of pure and applied microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.149

H-Index - 16

eISSN - 2581-690X

pISSN - 0973-7510

DOI - 10.22207/jpam.12.4.34

Subject(s) - mangrove , streptomyces , sediment , biology , ecology , botany , geography , bacteria , paleontology

Genus Streptomyces under phylum actinobacteria has been recognized as a prolific source for production of bioactive secondary metabolites. Actinobacterial strain designated as SKCMM1 isolated from Pichavaram Mangrove forest sediment was identified as Streptomyces cavourensis using polyphasic taxonomic approach. This strain shares 99% sequence similarity with Streptomyces cavourensis NBRC 13026T. Ethyl acetate fraction of the strain SKCMM1 exhibited highest biological activity. FTIR and GCMS analysis of crude compounds isolated from the active ethyl acetate fraction states the presence of several phenolic, hydrocarbon and fatty acid compounds with various bioactivities. This study will be an attempt to understand that the strain holds significant antimicrobial activity against test pathogens and antiproliferative activity against HeLa cell lines (IC50 value of 8.9μg/ml).

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