Antibiotic Susceptibility Pattern of Uropathogens towards Nitrofurontoin & Nalidixic Acid: A Comparitive Study

The objective of the study is to assess the sensitivity pattern of commonly isolated uropathogens towards the drugs Nitrofurontoin and Nalidixic acid. Widespread and irrational use of antibiotics has led to the development of highly resistant microorganisms. As the antibiotic sensitivity patterns of the microorganisms are frequently changing, this study was performed to assess the antibiotic sensitivity pattern of Nitrofurontoin and Nalidixic acid in urinary tract infections. This was a prospective, cross-sectional, observatory study conducted in the Department of Microbiology from January 2017 to July 2017 at RMMC, Chidambaram.300 culture positive urine samples were studied for the antibiotic susceptibility testing towards Nitrofurontoin and Nalidixic acid. The processing of the samples were done by standard microbiological methods. The antibiotic susceptibility was measured by disk diffusion test. CLSI guidelines were used for the antibiotic susceptibility evaluation[1]. Out of the 300 culture positive samples,the most common pathogen isolated in this study was E.coli(145),followed by Klebsiella(63), Staphylococcus aureus(35), Pseudomonas(36), Staphylococcus saprophyticus(10), Enterococcus(6), Sreptococcus(4), Proteus(1). The antibiotic susceptibility pattern for Nitrofurontoin : E.coli showed sensitivity (n=105) and resistance(40), Klebsiella showed sensitivity(47) and resistance(16), Staphylococcus aureus showed sensitivity(30) and resistance (5), Pseudomonas showed sensitivity(12) and resistance(24), Staphylococcus saprophyticus showed sensitivity(4) and resistance(2), Enterococcus showed sensitivity(5) and resistance (1), Streptococcus showed sensitivity (4) and resistance(0) and Proteus showed sensitivity (0) and resistance(1). The antibiotic susceptibility pattern for Nalidixic acid: E.coli showed sensitivity (n=23) and resistance(122), Klebsiella showed sensitivity(29) and resistance(43), Staphylococcus aureus showed sensitivity(9) and resistance (30), Pseudomonas showed sensitivity(4) and resistance(32), Staphylococcus saprophyticus showed sensitivity(2) and resistance(4), Enterococcus showed sensitivity(1) and resistance (5), Streptococcus showed sensitivity (0) and resistance(4) and Proteus showed sensitivity (0) and resistance(1). Urinary pathogens were more sensitive to Nitrofurontoin than Nalidixic acid. Klebsiella sp. was more sensitive towards Nitrofurontoin than E.coli. Hence Nitrofurontoin can be used as an effective drug in UTI.