Mineralization of regenerated cellulose hydrogels induced by human bone marrow stromal cells | Zendy

Pedro L. Granja | Zendy; B. DE JESO | Zendy; R. Bareille | Zendy; F. Rouais | Zendy; C. Baquey | Zendy; MA Barbosa | Zendy

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Mineralization of regenerated cellulose hydrogels induced by human bone marrow stromal cells

Author(s) -

Pedro L. Granja,

B. DE JESO,

R. Bareille,

F. Rouais,

C. Baquey,

MA Barbosa

Publication year - 2005

Publication title -

european cells and materials

Language(s) - English

Resource type - Journals

ISSN - 1473-2262

DOI - 10.22203/ecm.v010a04

Subject(s) - stromal cell , self healing hydrogels , mineralization (soil science) , cellulose , bone marrow , in vitro , microbiology and biotechnology , chemistry , materials science , biomedical engineering , biochemistry , biology , immunology , polymer chemistry , medicine , cancer research , organic chemistry , nitrogen

The proliferation of cultured human bone marrow stromal cells (HBMSC) on regenerated cellulose hydrogels was assessed. Regenerated cellulose hydrogels showed good rates of HBMSC proliferation, the cells exhibiting a flattened morphology, and after 22 days in culture, the cells had homogeneously colonized the surface of the materials. Moreover, since the early days in culture, between the surface of the materials and attached cells a continuous granulated hydroxyapatite layer was formed. It has been previously demonstrated in vitro, but without cells, that these materials did not mineralize. Hence, it seems that HBMSC promoted the mineralization of the surface.

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