Zeolitic Imidazolate Framework-8 Capped Mesoporous Silica Nanoparticles for pH-Controlled Drug Release | Zendy

Jiaxing Liu | Zendy; Xianxian Yao | Zendy; Yufang Zhu | Zendy

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Zeolitic Imidazolate Framework-8 Capped Mesoporous Silica Nanoparticles for pH-Controlled Drug Release

Author(s) -

Jiaxing Liu,

Xianxian Yao,

Yufang Zhu

Publication year - 2018

Publication title -

nano advances

Language(s) - English

Resource type - Journals

ISSN - 2415-1386

DOI - 10.22180/na219

Subject(s) - zeolitic imidazolate framework , imidazolate , mesoporous silica , nanoparticle , mesoporous material , controlled release , drug , chemical engineering , chemistry , materials science , nanotechnology , inorganic chemistry , metal organic framework , adsorption , organic chemistry , pharmacology , catalysis , medicine , engineering

We proposed a strategy to construct zeolitic imidazolate framework-8 (ZIF-8) capped mesoporous silica nanoparticles (MSN) for potential pH-controlled drug release. The structure, drug loading and release behavior of the ZIF-8 capped MSN nanocarriers were evaluated. The results showed that ZIF-8 capped MSN nanoparticles had a core-shell structure. Using camptothecin (CPT) as a model anticancer drug, the CPT-loaded MSN/ZIF-8 nanoparticles could release CPT rapidly in pH 4.5 solution, but very slow in pH 7.4 solution, indicating pH-dependent drug release behavior. Therefore, ZIF-8 capped MSN nanoparticles have great potential for cancer therapy with pH-controlled drug release.

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