Open AccessWeight Gain After Oophorectomy Among Women with a BRCA1 or BRCA2 Mutation
Author(s) -
Joanne Kotsopoulos,
Jan Lubiński,
Susan L. Neuhausen,
Jacek Gronwald,
Henry T. Lynch,
Tomasz Huzarski,
Rochelle Demsky,
William D. Foulkes,
Leigha Senter,
Susan Friedman,
Peter Ainsworth,
Ping Sun,
Steven A. Narod
Publication year - 2015
Publication title -
women s health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.363
H-Index - 39
eISSN - 1745-5065
pISSN - 1745-5057
DOI - 10.2217/whe.15.4
Subject(s) - oophorectomy , medicine , weight gain , gynecology , weight loss , brca mutation , obstetrics , cancer , ovarian cancer , surgery , body weight , hysterectomy , obesity
Aim: To measure weight gain among unaffected women with a BRCA1 or BRCA2 mutation after undergoing an oophorectomy. Patients & methods: We compared the bodyweight of women with (n = 405) and without an oophorectomy (n = 741) at baseline as well as the rate of weight change prior to and following surgery among 1454 BRCA mutation carriers who had an oophorectomy. Results: There was a small and non-significant difference in bodyweight between BRCA mutation carriers who had an oophorectomy compared with those women who did not (151.5 vs 149.1 pounds; p = 0.26). There was an increase in bodyweight with increasing age, but this relationship did not differ prior to and following surgery (p comparing the slope parameters = 0.78). Conclusion: Oophorectomy is not associated with significant weight gain in high-risk women.
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