Efficacy and Safety of Oral Tranexamic Acid in Women with Heavy Menstrual Bleeding and Fibroids | Zendy

Scott Evan Eder | Zendy; Jeffrey Baker | Zendy; Janet Gersten | Zendy; R. Garn Mabey | Zendy; Tammie L Adomako | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Efficacy and Safety of Oral Tranexamic Acid in Women with Heavy Menstrual Bleeding and Fibroids

Author(s) -

Scott Evan Eder,

Jeffrey Baker,

Janet Gersten,

R. Garn Mabey,

Tammie L Adomako

Publication year - 2013

Publication title -

women s health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.363

H-Index - 39

eISSN - 1745-5065

pISSN - 1745-5057

DOI - 10.2217/whe.13.28

Subject(s) - tranexamic acid , medicine , menstrual bleeding , obstetrics , uterine fibroids , hysteroscopy , gynecology , blood loss , surgery

Aim: To evaluate the efficacy and safety of oral, modified-release tranexamic acid in women with heavy menstrual bleeding and fibroids. Materials & methods: This was a pooled analysis of two pivotal Phase III studies. Fibroids were evaluated by transvaginal ultrasonography. Menstrual blood loss (MBL) was measured via a validated alkaline hematin method. Results: In women with and without fibroids, mean MBL was reduced compared with placebo across all treatment cycles (p < 0.001). Within the tranexamic acid group, more statistically significant (p < 0.001) reductions in MBL compared with placebo occurred in women with fibroids than in those without fibroids. Adverse events were similar between treatment groups. Conclusion: Tranexamic acid was well tolerated and reduced MBL in women with and without fibroids.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research