BRCACarriers, Prophylactic Salpingo-Oophorectomy and Menopause: Clinical Management Considerations and Recommendations | Zendy

Amy Finch | Zendy; D. Gareth Evans | Zendy; Steven A. Narod | Zendy

Open Access

BRCACarriers, Prophylactic Salpingo-Oophorectomy and Menopause: Clinical Management Considerations and Recommendations

Author(s) -

Amy Finch,

D. Gareth Evans,

Steven A. Narod

Publication year - 2012

Publication title -

women s health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.363

H-Index - 39

eISSN - 1745-5065

pISSN - 1745-5057

DOI - 10.2217/whe.12.41

Subject(s) - medicine , prophylactic surgery , menopause , gynecology , breast cancer , ovarian cancer , oophorectomy , obstetrics , fallopian tube , salpingectomy , brca mutation , quality of life (healthcare) , cancer , hysterectomy , surgery , nursing , pregnancy , biology , genetics , ectopic pregnancy

Women who inherit a mutation in either the BRCA1 or BRCA2 gene have greatly elevated lifetime risks of ovarian cancer, fallopian tube cancer and breast cancer. Preventive surgical removal of the ovaries and fallopian tubes (salpingo-oophorectomy) is recommended to these women, often prior to natural menopause, to prevent cancer. The ensuing hormone deprivation may impact on health and quality of life. Most of these women experience menopausal symptoms shortly after surgery; however, there may also be longer term consequences that are less well understood. In this review, we highlight recent studies that examine the implications of salpingo-oophorectomy on health and quality of life in BRCA-positive women and we discuss the care of women following prophylactic surgery.

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