A review of induced pluripotent stem cell, direct conversion by trans-differentiation, direct reprogramming and oligodendrocyte differentiation | Zendy

Ankshita Prasad | Zendy; Janani Manivannan | Zendy; Daniel Boon Loong Teh | Zendy; Soo Min Chua | Zendy; Payam Gharibani | Zendy; Angelo H. All | Zendy

Open Access

A review of induced pluripotent stem cell, direct conversion by trans-differentiation, direct reprogramming and oligodendrocyte differentiation

Author(s) -

Ankshita Prasad,

Janani Manivannan,

Daniel Boon Loong Teh,

Soo Min Chua,

Payam Gharibani,

Angelo H. All

Publication year - 2016

Publication title -

regenerative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.572

H-Index - 63

eISSN - 1746-076X

pISSN - 1746-0751

DOI - 10.2217/rme.16.5

Subject(s) - reprogramming , induced pluripotent stem cell , context (archaeology) , biology , progenitor cell , stem cell , cell potency , cellular differentiation , somatic cell , oligodendrocyte , microbiology and biotechnology , cell , neuroscience , myelin , embryonic stem cell , genetics , paleontology , gene , central nervous system

Rapid progress in the field of stem cell therapy and cellular reprogramming provides convincing evidence of its feasibility in treating a wide range of pathologies through autologous cell replacement therapy. This review article describes in detail on three widely used approaches of somatic cell reprogramming: induced pluripotent stem cells, direct conversion and direct reprogramming, in the context of demyelination in the CNS. The potential limitations of each reprogramming technique are reviewed along with their distinct molecular approach to reprogramming. This is followed by an analysis on the scopes and challenges of its translational applications in deriving oligodendrocyte progenitor cells and oligodendrocytes for cell replacement treatment of demyelinating conditions in the CNS.

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