Influence of common and rare genetic variation on warfarin dose among African–Americans and European–Americans using the exome array | Zendy

Nianjun Liu | Zendy; Marguerite R. Irvin | Zendy; Degui Zhi | Zendy; Amit Patki | Zendy; T. Mark Beasley | Zendy; Deborah A. Nickerson | Zendy; Charles E. Hill | Zendy; Jinbo Chen | Zendy; Stephen E. Kimmel | Zendy; Nita A. Limdi | Zendy

Open Access

Influence of common and rare genetic variation on warfarin dose among African–Americans and European–Americans using the exome array

Author(s) -

Nianjun Liu,

Marguerite R. Irvin,

Degui Zhi,

Amit Patki,

T. Mark Beasley,

Deborah A. Nickerson,

Charles E. Hill,

Jinbo Chen,

Stephen E. Kimmel,

Nita A. Limdi

Publication year - 2017

Publication title -

pharmacogenomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.541

H-Index - 91

eISSN - 1744-8042

pISSN - 1462-2416

DOI - 10.2217/pgs-2017-0046

Subject(s) - warfarin , single nucleotide polymorphism , vkorc1 , exome , exome sequencing , genome wide association study , genetic variation , biology , genetic association , genetics , medicine , gene , pharmacogenetics , mutation , genotype , atrial fibrillation

Aim: We conducted a genome-wide association study using the Illumina Exome Array to identify coding SNPs that may explain additional warfarin dose variability. Patients & methods: Analysis was performed after adjustment for clinical variables and genetic factors known to influence warfarin dose among 1680 warfarin users (838 European–Americans and 842 African–Americans). Replication was performed in an independent sample. Results: We confirmed the influence of known genetic variants on warfarin dose variability. Our study is the first to show the association between rs12772169 and warfarin dose in African–Americans. In addition, genes COX15 and FGF5 showed significant association in European–Americans. Conclusion: We identified some novel genes/SNPs that underpin warfarin dose response. Further replication is needed to confirm our findings.

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