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Aim: To explore the association between VDR polymorphisms and several cardiovascular risk factors and adiponectin. Materials &amp; methods: Three-hundred and sixty-nine healthy students were randomly selected. Five VDR polymorphisms were genotyped: BsmI rs1544410; Cdx2 rs11568820; ApaI rs7975232; TaqI rs731236 and FokI rs2228570. BMI, waist circumference (WC), blood pressure, lipid/glycemic profiles and adiponectin were assessed. Results: In men, BsmI, ApaI and TaqI were associated with BMI and WC (p &lt; 0.05). FokI was associated with triglycerides and high-density lipoprotein levels (p = 0.0036; p = 0.005) whereas BsmI and Cdx2 were associated with adiponectin levels (p = 0.026; p = 0.048). Associations disappeared after BMI and WC adjustments. In women, ApaI was associated with systolic blood pressure (p = 0.02). Conclusion: Our study demonstrated a gender-specific difference between VDR SNPs and various cardiovascular risk factors and adiponectin.

Relationship between vitamin D receptor gene polymorphisms, cardiovascular risk factors and adiponectin in a healthy young population