Relationship between Vitamin D Receptor Gene Polymorphisms, Cardiovascular Risk Factors and Adiponectin in a Healthy Young Population | Zendy

Aline Hajj | Zendy; Rima Chédid | Zendy; Éliane Chouery | Zendy; André Mégarbané | Zendy; MarieHélène GannagéYared | Zendy

Open Access

Relationship between Vitamin D Receptor Gene Polymorphisms, Cardiovascular Risk Factors and Adiponectin in a Healthy Young Population

Author(s) -

Aline Hajj,

Rima Chédid,

Éliane Chouery,

André Mégarbané,

MarieHélène GannagéYared

Publication year - 2016

Publication title -

pharmacogenomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.541

H-Index - 91

eISSN - 1744-8042

pISSN - 1462-2416

DOI - 10.2217/pgs-2016-0045

Subject(s) - foki , taqi , adiponectin , calcitriol receptor , medicine , endocrinology , blood pressure , single nucleotide polymorphism , waist , population , vitamin d and neurology , body mass index , polymorphism (computer science) , biology , allele , genotype , obesity , insulin resistance , genetics , gene , environmental health

Aim: To explore the association between VDR polymorphisms and several cardiovascular risk factors and adiponectin. Materials & methods: Three-hundred and sixty-nine healthy students were randomly selected. Five VDR polymorphisms were genotyped: BsmI rs1544410; Cdx2 rs11568820; ApaI rs7975232; TaqI rs731236 and FokI rs2228570. BMI, waist circumference (WC), blood pressure, lipid/glycemic profiles and adiponectin were assessed. Results: In men, BsmI, ApaI and TaqI were associated with BMI and WC (p < 0.05). FokI was associated with triglycerides and high-density lipoprotein levels (p = 0.0036; p = 0.005) whereas BsmI and Cdx2 were associated with adiponectin levels (p = 0.026; p = 0.048). Associations disappeared after BMI and WC adjustments. In women, ApaI was associated with systolic blood pressure (p = 0.02). Conclusion: Our study demonstrated a gender-specific difference between VDR SNPs and various cardiovascular risk factors and adiponectin.

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