Scaffold-Free Scleraxis-Programmed Tendon Progenitors Aid in Significantly Enhanced Repair of Full-Size Achilles Tendon Rupture | Zendy

Chi-Fen Hsieh | Zendy; Paolo Alberton | Zendy; Eva LoffredoVerde | Zendy; Elias Volkmer | Zendy; Matthias F. Pietschmann | Zendy; Peter E. Müller | Zendy; Matthias Schieker | Zendy; Denitsa Docheva | Zendy

Open Access

Scaffold-Free Scleraxis-Programmed Tendon Progenitors Aid in Significantly Enhanced Repair of Full-Size Achilles Tendon Rupture

Author(s) -

Chi-Fen Hsieh,

Paolo Alberton,

Eva LoffredoVerde,

Elias Volkmer,

Matthias F. Pietschmann,

Peter E. Müller,

Matthias Schieker,

Denitsa Docheva

Publication year - 2016

Publication title -

nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.947

H-Index - 109

eISSN - 1748-6963

pISSN - 1743-5889

DOI - 10.2217/nnm.16.34

Subject(s) - achilles tendon , scaffold , tendon , progenitor cell , medicine , surgery , anatomy , stem cell , biology , microbiology and biotechnology , biomedical engineering

Aim: Currently there is no effective approach to enhance tendon repair, hence we aimed to identify a suitable cell source for tendon engineering utilizing an established clinically relevant animal model for tendon injury. Materials & methods: We compared, by in-depth histomorphometric evaluation, the regenerative potential of uncommitted human mesenchymal stem cells (hMSC) and Scleraxis (Scx)-programmed tendon progenitors (hMSC-Scx) in the healing of a full-size of rat Achilles tendon defect. Results: Our analyses clearly demonstrated that implantation of hMSC-Scx, in contrast to hMSC and empty defect, results in smaller diameters, negligible ectopic calcification and advanced cellular organization and matrix maturation in the injured tendons. Conclusion: Scaffold-free delivery of hMSC-Scx aids in enhanced repair in a clinically translatable Achilles tendon injury model.

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