Multifunctional Nanoagent for Thrombus-Targeted Fibrinolytic Therapy | Zendy

Jason R. McCarthy | Zendy; I.Y. Sazonova | Zendy; S. Sibel Erdem | Zendy; Tetsuya Hara | Zendy; Brian Thompson | Zendy; Purvish Patel | Zendy; Ion Botnaru | Zendy; Charles P. Lin | Zendy; Guy L. Reed | Zendy; Ralph Weissleder | Zendy; Farouc A. Jaffer | Zendy

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Multifunctional Nanoagent for Thrombus-Targeted Fibrinolytic Therapy

Author(s) -

Jason R. McCarthy,

I.Y. Sazonova,

S. Sibel Erdem,

Tetsuya Hara,

Brian Thompson,

Purvish Patel,

Ion Botnaru,

Charles P. Lin,

Guy L. Reed,

Ralph Weissleder,

Farouc A. Jaffer

Publication year - 2012

Publication title -

nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.947

H-Index - 109

eISSN - 1748-6963

pISSN - 1743-5889

DOI - 10.2217/nnm.11.179

Subject(s) - fibrinolysis , thrombus , in vivo , intravital microscopy , hemostasis , in vitro , fibrinolytic agent , pharmacology , thrombolytic drug , medicine , materials science , biochemistry , chemistry , tissue plasminogen activator , thrombolysis , biology , surgery , microbiology and biotechnology , myocardial infarction

Current thrombolytic therapies utilize exogenous plasminogen activators (PAs) to effectively lyse clots, restoring blood flow, and preventing tissue and organ death. These PAs may also impair normal hemostasis, leading to life-threatening bleeding, including intracerebral hemorrhage.

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