Open AccessPreparation, structure, Cytotoxicity and Mechanism of Action of ferritin-Pt(II) Terpyridine Compound Nanocomposites
Author(s) -
Giarita Ferraro,
Andrea Pica,
Ganna Petruk,
Francesca Pane,
Angela Amoresano,
Agostino Cilibrizzi,
Ramón Vilar,
Daria Maria Monti,
Antonello Merlino
Publication year - 2018
Publication title -
nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.947
H-Index - 109
eISSN - 1748-6963
pISSN - 1743-5889
DOI - 10.2217/nnm-2018-0259
Subject(s) - terpyridine , cisplatin , cytotoxicity , nanocomposite , piperidine , chemistry , nanocages , cancer cell , ligand (biochemistry) , mechanism of action , cytotoxic t cell , ferritin , platinum , stereochemistry , in vitro , combinatorial chemistry , materials science , metal , nanotechnology , biochemistry , organic chemistry , cancer , receptor , medicine , surgery , chemotherapy , catalysis
A Pt(II)-terpyridine compound, bearing two piperidine substituents at positions 2 and 2' of the terpyridine ligand (1), is highly cytotoxic and shows a mechanism of action distinct from cisplatin. 1 has been incorporated within the ferritin nanocage (AFt).
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