Measurement of respiratory function decline in patients with Duchenne muscular dystrophy: a conjoint analysis | Zendy

Elena Ripamonti | Zendy; Maria Grazia D’Angelo | Zendy

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Measurement of respiratory function decline in patients with Duchenne muscular dystrophy: a conjoint analysis

Author(s) -

Elena Ripamonti,

Maria Grazia D’Angelo

Publication year - 2018

Publication title -

neurodegenerative disease management

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.674

H-Index - 23

eISSN - 1758-2032

pISSN - 1758-2024

DOI - 10.2217/nmt-2017-0052

Subject(s) - duchenne muscular dystrophy , vital capacity , conjoint analysis , medicine , dysphagia , physical therapy , muscular dystrophy , pulmonary function testing , neuromuscular disease , scale (ratio) , physical medicine and rehabilitation , disease , lung function , preference , surgery , diffusing capacity , statistics , physics , mathematics , quantum mechanics , lung

Aim: In Duchenne muscular dystrophy (DMD), little attention has been paid to severity of respiratory function decline (RFD) based on disease progression. We performed a conjoint analysis among 123 Italian clinicians to generate a scale for RFD in DMD patients. Methods: Before the interview, 11 attributes were selected by discussion among experts. 32 ‘patient profiles’ were generated. Each physician assessed the severity of RFD for each profile. Each level/attribute was assigned an estimated usefulness to understand its impact on RFD. Results: The identified attributes were forced vital capacity, forced vital capacity decline, dysphagia, type of ventilation and peak cough flow. These results allowed the development of a scale for RFD severity. Conclusion: This scale can stratify DMD patients according to the severity of their RFD.

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