Targeting claudin-3 suppresses stem cell-like phenotype in nonsquamous non-small-cell lung carcinoma | Zendy

Lin Ma | Zendy; Wu Yin | Zendy; Heliang Ma | Zendy; Ihab Elshoura | Zendy; Lan Wang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Targeting claudin-3 suppresses stem cell-like phenotype in nonsquamous non-small-cell lung carcinoma

Author(s) -

Lin Ma,

Wu Yin,

Heliang Ma,

Ihab Elshoura,

Lan Wang

Publication year - 2019

Publication title -

lung cancer management

Language(s) - English

Resource type - Journals

eISSN - 1758-1974

pISSN - 1758-1966

DOI - 10.2217/lmt-2018-0010

Subject(s) - claudin , stem cell , phenotype , small cell lung carcinoma , lung , cancer research , medicine , carcinoma , cell , oncology , small cell carcinoma , biology , pathology , microbiology and biotechnology , tight junction , gene , genetics

Claudin-3 depletion decreased the formation rates of spheres and tumors and increased cisplatin sensitivity. Claudin-3 was also identified as one downstream target of estrogen receptor-α in regulating cancer stemness. Moreover, targeting transcription by small molecules including withaferin A, estradiol and fulvestrant suppressed cancer stemness and reversed chemoresistance. These results demonstrated claudin-3 is one positive regulator of cancer stemness in nonsuqamous NSCLC.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research