Open AccessRe-Education of Macrophages as a Therapeutic Strategy in Cancer
Author(s) -
Joanna Kowal,
Mara Kornete,
Johanna A. Joyce
Publication year - 2019
Publication title -
immunotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.127
H-Index - 48
eISSN - 1750-7448
pISSN - 1750-743X
DOI - 10.2217/imt-2018-0156
Subject(s) - tumor microenvironment , cancer , perspective (graphical) , tumor associated macrophage , immunotherapy , macrophage , cancer research , immune system , medicine , tumor progression , cancer immunotherapy , immunology , biology , computer science , biochemistry , artificial intelligence , in vitro
Tumor-associated macrophages (TAMs) can be educated within the tumor microenvironment to promote cancer development and progression. While TAM-targeted agents have largely focused on macrophage depletion as an anticancer strategy, it is becoming increasingly evident that TAM re-education may represent a more effective approach. In this perspective, we discuss different means to achieve TAM re-education, and review the beneficial effects of these strategies, particularly when combined with immune checkpoint inhibitors.
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