Efficacy of Radioembolization According to Tumor Morphology and Portal Vein Thrombosis in Intermediate–Advanced Hepatocellular Carcinoma | Zendy

Rita Golfieri | Zendy; Cristina Mosconi | Zendy; Alberta Cappelli | Zendy; Emanuela Giampalma | Zendy; Maria Cristina Galaverni | Zendy; Cinzia Pettinato | Zendy; Matteo Renzulli | Zendy; Fabio Monari | Zendy; Bruna Angelelli | Zendy; Patrizia Pini | Zendy; Eleonora Terzi | Zendy; Salvatore Ascanio | Zendy; Giorgio Garzillo | Zendy; Fabio Piscaglia | Zendy; Luigi Bolondi | Zendy; Franco Trevisani | Zendy

Open Access

Efficacy of Radioembolization According to Tumor Morphology and Portal Vein Thrombosis in Intermediate–Advanced Hepatocellular Carcinoma

Author(s) -

Rita Golfieri,

Cristina Mosconi,

Alberta Cappelli,

Emanuela Giampalma,

Maria Cristina Galaverni,

Cinzia Pettinato,

Matteo Renzulli,

Fabio Monari,

Bruna Angelelli,

Patrizia Pini,

Eleonora Terzi,

Salvatore Ascanio,

Giorgio Garzillo,

Fabio Piscaglia,

Luigi Bolondi,

Franco Trevisani

Publication year - 2015

Publication title -

future oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.857

H-Index - 72

eISSN - 1744-8301

pISSN - 1479-6694

DOI - 10.2217/fon.15.267

Subject(s) - medicine , hepatocellular carcinoma , portal vein thrombosis , radiology , thrombosis , portal vein

Purpose: We analyzed overall survival (OS) following radioembolization according to macroscopic growth pattern (nodular vs infiltrative) and vascular invasion in intermediate–advanced hepatocellular carcinoma (HCC). Methods: Between September 2005 and November 2013, 104 patients (50.0% portal vein thrombosis [PVT], 29.8% infiltrative morphology) were treated. Results: Median OS differed significantly between patients with segmental and lobar or main PVT (p = 0.031), but was 17 months in both those with patent vessels and segmental PVT. Median OS did not differ for infiltrative and nodular HCC. Median OS was prolonged in patients with a treatment response at 3 months (p = 0.023). Prior TACE was also a significant predictor of improved OS. Conclusion: A further indication for radioembolization might be infiltrative HCC, since OS was similar to nodular types.

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