Tumor Necrosis and >20 mitoses Per 50 High-Power Fields can Distinguish ‘Very High-Risk’ and ‘Highest-Risk’ within ‘High-Risk’ Gastric Gastrointestinal Stromal Tumor | Zendy

Jiabin Zheng | Zendy; Renjie Li | Zendy; Haibo Qiu | Zendy; Tao Chen | Zendy; Yongjian Zhou | Zendy; ChangMing Huang | Zendy; Guoxin Li | Zendy; Zhiwei Zhou | Zendy; Yong Li | Zendy

Open Access

Tumor Necrosis and >20 mitoses Per 50 High-Power Fields can Distinguish ‘Very High-Risk’ and ‘Highest-Risk’ within ‘High-Risk’ Gastric Gastrointestinal Stromal Tumor

Author(s) -

Jiabin Zheng,

Renjie Li,

Haibo Qiu,

Tao Chen,

Yongjian Zhou,

ChangMing Huang,

Guoxin Li,

Zhiwei Zhou,

Yong Li

Publication year - 2018

Publication title -

future oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.857

H-Index - 72

eISSN - 1744-8301

pISSN - 1479-6694

DOI - 10.2217/fon-2017-0509

Subject(s) - univariate , medicine , necrosis , stromal cell , univariate analysis , mitotic index , multivariate analysis , multivariate statistics , oncology , high power field , gastroenterology , pathology , mitosis , immunohistochemistry , biology , statistics , mathematics , microbiology and biotechnology

Aim: We aimed to investigate the optimal criteria for classifying higher risk forms of gastric gastrointestinal stromal tumor (gGIST). Materials & methods: A total of 246 high-risk gGIST patients were enrolled. Univariate and multivariate analyses were conducted to determine the association between clinicopathological features and overall survival. Appropriate cut-off values were calculated to identify those at higher risk of gGIST. Results: Multivariate and univariate analyses revealed that tumor necrosis and mitotic counts are independent risk factors for overall survival. The optimal cut-off value of mitotic counts was 20. Patients with both necrosis and >20 mitoses/50 high-power fields were worse than those with either one. Conclusion: Tumor necrosis and >20 mitoses/50 high-power fields are independent risk factors for high-risk gGIST. Patients with both risk factors indicate worse prognosis.

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