Interaction Between Helicobacter Pylori and Host Genetic Variants in Gastric Carcinogenesis | Zendy

Zhifang Jia | Zendy; Song-Ling Zhang | Zendy; Xueyuan Cao | Zendy; Baosen Zhou | Zendy; Jing Jiang | Zendy

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Interaction Between Helicobacter Pylori and Host Genetic Variants in Gastric Carcinogenesis

Author(s) -

Zhifang Jia,

Song-Ling Zhang,

Xueyuan Cao,

Baosen Zhou,

Jing Jiang

Publication year - 2016

Publication title -

future oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.857

H-Index - 72

eISSN - 1744-8301

pISSN - 1479-6694

DOI - 10.2217/fon-2016-0233

Subject(s) - helicobacter pylori , carcinogenesis , cancer , dna methylation , gene , methylation , genetic predisposition , medicine , biology , cancer research , genetics , immunology , gene expression

Helicobacter pylori (H. pylori) is the definite carcinogen of gastric cancer. H. pylori infection induces chronic inflammation, causes DNA damage and aberrant methylation of genes and these pathways are involved in H. pylori-related gastric carcinogenesis. Polymorphisms of the genes involved in these pathways could alter susceptibility to gastric cancer. In this mini review, we focused on the role of polymorphisms in these genes on the susceptibility to gastric cancer, with a particular emphasis on their possible interactions with H. pylori infection. We found that many studies on this theme did not simultaneously report H. pylori infection and the interactions remained inconclusive.

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