Open AccessTranslocation of effectors: revisiting the injectosome model
Author(s) -
Neta SalMan,
Matthew A. Croxen,
B. Brett Finlay
Publication year - 2011
Publication title -
future microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.797
H-Index - 82
eISSN - 1746-0921
pISSN - 1746-0913
DOI - 10.2217/fmb.11.33
Subject(s) - effector , secretion , chromosomal translocation , type three secretion system , microbiology and biotechnology , cytosol , virulence , biology , chemistry , biochemistry , gene , enzyme
Evaluation of: Akopyan K, Edgren T, Wang-Edgren H et al.: Translocation of surface-localized effectors in type III secretion. Proc. Natl Acad. Sci. USA 108(4), 1639–1644 (2011). Type III secretion systems suppress host immune response and modify cell-signaling and regulation pathways by translocation of virulence proteins, called effectors, from the bacteria into the cytosol of the target cells. The common belief was that effectors translocate by a single step mechanism through a continuous channel built up by type III secretion systems. In this article, Akopyan et al. propose an alternative, and possibly parallel, two-step model to translocate effectors into target cells. According to their model, effectors first localized on the surface of the bacterial membrane, followed by a type III secretion system-dependent entry into the host cell.