DNA methylation fingerprint of neuroblastoma reveals new biological and clinical insights | Zendy

Soledad Gómez | Zendy; Giancarlo Castellano | Zendy; Gemma Mayol | Zendy; Mariona Suñol | Zendy; Ana C. Queirós | Zendy; Marina Bibikova | Zendy; Kristopher L. Nazor | Zendy; Jeanne F. Loring | Zendy; Isadora Lemos | Zendy; Eva Rodríguez | Zendy; Carmen de Torres | Zendy; Jaume Mora | Zendy; José I. MartínSubero | Zendy; Cinzia Lavarino | Zendy

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DNA methylation fingerprint of neuroblastoma reveals new biological and clinical insights

Author(s) -

Soledad Gómez,

Giancarlo Castellano,

Gemma Mayol,

Mariona Suñol,

Ana C. Queirós,

Marina Bibikova,

Kristopher L. Nazor,

Jeanne F. Loring,

Isadora Lemos,

Eva Rodríguez,

Carmen de Torres,

Jaume Mora,

José I. MartínSubero,

Cinzia Lavarino

Publication year - 2015

Publication title -

epigenomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.265

H-Index - 60

eISSN - 1750-1911

pISSN - 1750-192X

DOI - 10.2217/epi.15.49

Subject(s) - biology , dna methylation , cpg site , epigenetics , methylation , neuroblastoma , genetics , epigenomics , cancer research , differentially methylated regions , illumina methylation assay , gene , gene expression , cell culture

Aim: To define the DNA methylation landscape of neuroblastoma and its clinicopathological impact. Materials & methods: Microarray DNA methylation data were analyzed and associated with functional/regulatory genome annotation data, transcriptional profiles and clinicobiological parameters. Results: DNA methylation changes in neuroblastoma affect not only promoters but also intragenic and intergenic regions at cytosine-phosphate-guanine (CpG) and non-CpG sites, and target functional chromatin domains of development and cancer-related genes such as CCND1. Tumors with diverse clinical risk showed differences affecting CpG and, remarkably, non-CpG sites. Non-CpG methylation observed essentially in clinically favorable cases was associated with the differentiation status of neuroblastoma and expression of key genes such as ALK. Conclusion: This epigenetic fingerprint of neuroblastoma provides new insights into the pathogenesis and clinical behavior of this pediatric tumor.

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